Molecular Formula | C7H9ClO6P2S |
Molar Mass | 318.61 |
Solubility | H2O: >10mg/mL, clear |
Appearance | powder |
Color | white to off-white |
pKa | pK1 10.85; pK2 6.90; pK3 2.95; pK4 1.30(at 25℃) |
Storage Condition | room temp |
Physical and Chemical Properties | pKl 10.85;pK2 6.90;pK3 2.95;pKa41.30. Te-tert-butylamine Tiludronic Acid Di-tert-butylamine Salt: Melting point 253 ℃ (decomposition). |
WGK Germany | 3 |
use | anti-inflammatory and analgesic drugs. It is used to treat Paget's disease. |
production method | tetramethylene diphosphonate is dissolved in dimethylformamide, under the protection of nitrogen, sodium hydride is added at 15 ℃ and stirred for 1h. Then 4-chlorophenyl disulfide was added and stirred at 25°C to obtain tetramethyl terudronate. Hydrolysis can obtain tirudronic acid. |